Quick Study: Introduction to Tuberous Sclerosis Complex (TSC) and Epilepsy

APRIL 3 - MAY 8, 2025 | 12:00 PM - 1:00 PM (EST) | THURSDAYS WEEKLY
Tuberous sclerosis complex (TSC) is a multisystem disorder that can cause both epilepsy related and non-epilepsy related complications that family care providers may encounter. This curriculum aims to provide evidence-based education regarding management and treatment of TSC, TSC-associated epilepsy and other TSC comorbidities for health care providers caring for children and youth, and adults living with epilepsy.

Case Support
Healthcare providers can present your de-identified case for advice, support and written recommendations.


This Quick Study series is facilitated by epilepsy specialists from the Children’s Hospital of Eastern Ontario (CHEO) and McMaster Children’s Hospital.
Syllabus
- Review the clinical diagnostic criteria for TSC, including dermatological findings
- Describe the genetic components associated with TSC and implications for patient care
- Describe the mechanism of action and indications for Everolimus in TSC treatment
- Discuss the use of Everolimus for epilepsy, subependymal giant cell astrocytomas (SEGA), and AMLs
- Explain the use of Vigabatrin in treating epilepsy associated with TSC
- Discuss the efficacy and safety profiles of other standard ASMs in TSC
- Define TAND and identify its manifestations in patients with TSC
- Understand the contribution of epilepsy and ASM use to neuropsychiatric symptoms
- Discuss management strategies to address TAND in clinical practice
- Review surgical options, including indications and outcomes, for epilepsy management in TSC
- Discuss non-surgical treatments for management of refractory epilepsy
- Recognize renal angiomyolipomas (AML) and other renal manifestations of TSC
- Assess the impact of ASM medications on renal function in patients with TSC
Didactics & Recordings
Clinical Leads

Dr. Katherine Muir, Paediatric Neurologist
Medical Co-Lead | CHEO

Nevena Simic, Neuropsychologist
McMaster Children's Hospital

Jennifer Flinn, Principal (Ottawa)
TSC Canada representative