Quick Study: Introduction to Tuberous Sclerosis Complex (TSC) and Epilepsy

Seizures occur in up to 90 percent of people with TSC and TSC is the leading genetic cause of epilepsy. ^1.

APRIL 3 - MAY 8, 2025 | 12:00 PM - 1:00 PM (EST) | THURSDAYS WEEKLY

Tuberous sclerosis complex (TSC) is a multisystem disorder that can cause both epilepsy related and non-epilepsy related complications that family care providers may encounter. This curriculum aims to provide evidence-based education regarding management and treatment of TSC, TSC-associated epilepsy and other TSC comorbidities for health care providers caring for children and youth, and adults living with epilepsy.

Case Support

Healthcare providers can present your de-identified case for advice, support and written recommendations.

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This Quick Study series is facilitated by epilepsy specialists from the Children’s Hospital of Eastern Ontario (CHEO) and McMaster Children’s Hospital.

Syllabus

Introduction to Tuberous Sclerosis Complex (TSC)

Review the clinical diagnostic criteria for TSC, including dermatological findings
Describe the genetic components associated with TSC and implications for patient care

Use of Everolimus in TSC

Describe the mechanism of action and indications for Everolimus in TSC treatment
Discuss the use of Everolimus for epilepsy, subependymal giant cell astrocytomas (SEGA), and AMLs

ASM for Epilepsy in TSC

Explain the use of Vigabatrin in treating epilepsy associated with TSC
Discuss the efficacy and safety profiles of other standard ASMs in TSC

Tuberous Sclerosis Associated Neuropsychiatric Disorder

Define TAND and identify its manifestations in patients with TSC
Understand the contribution of epilepsy and ASM use to neuropsychiatric symptoms
Discuss management strategies to address TAND in clinical practice

Advanced management of epilepsy

Review surgical options, including indications and outcomes, for epilepsy management in TSC
Discuss non-surgical treatments for management of refractory epilepsy